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Journal of Visualized Experiments |
Journal of Visualized Experiments (JoVE) (http://www.jove.com) is a peer reviewed, online journal devoted to the publication of biological research in a video format. JoVE uses video technology to capture and transmit the life science research thus facilitating the understanding and efficient reproduction of experimental techniques. The journal is listed in PubMed and can be cited as any peer reviewed publication. |
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Selected video publications |
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The advent of MEG systems sized for
young children opens important new opportunities to study
brain development. The new system, together with a protocol
that aligns experimental requirements with the capacities of
children, can be used to study cognitive and language
processes in healthy, awake children aged three to
six. |
Elevated Plus Maze for Mice |
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The elevated plus maze test is one of
the most widely used tests for measuring anxiety-like
behavior in mice. This video shows the detailed procedures
for conducting the test. |
Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring |
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This presentation demonstrates the use
of fMRI to study neural circuits that underlie
decision-making. Simple perceptual tasks are combined with
appetitive and aversive reinforcements to investigate how
outcomes affect decision processes. |
Morris Water Maze Experiment |
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The Morris water maze is widely used
to study spatial memory and learning. Animals are placed in
a pool of opaque water where they must swim to a submerged
platform. Since the animals cannot see the platform, they
must rely on external/extra-maze cues. As the animals become
more familiar with the task, they are able to find the
platform more quickly. Developed by Richard G. Morris in
1984, this paradigm has become one of the "gold standards"
of behavioral neuroscience. |
Survivable Stereotaxic Surgery in Rodents |
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The monitoring of extracellular
neurotransmitter levels in distinct brain regions of freely
moving animals offers insights on the link between
neurotransmitter release and behavior. In vivo microdialysis
coupled with electrochemical detection provides excellent
anatomical and chemical resolution; and information on how
basal neurotransmission is altered by pharmacological or
physiological manipulations. |
Neuronal Nuclei Isolation from Human Postmortem Brain Tissue |
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The cellular heterogeneity of brain
tissue poses a significant limitation for the study of
epigenetic markings in chromatin because most assays lack
single cell resolution. Neurons typically are intermingled
with glia and other non-neuronal cells. We provide a
protocol to extract and collect neuronal nuclei from human
brain. |
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Updated February 2010