|
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Side-effects
of antidepressants
(1,2)
Please
note: Clicking on the link on the reference
numbers, for example [1]
will open a window with the full reference.
Please remember to close the Reference
window.
|
Receptor
implicated
|
Adverse
effect
|
%
Occurence or frequency level (0,
+,
++, +++)
|
|
TCA
|
SSRI
|
SNRI
|
|
|
|
|
|
milnacipran
|
venlafaxine
|
|
|
|
Muscarinic
cholinergic antagonism
|
Dry
mouth
|
37
|
4
|
8
|
22
|
|
Constipation
|
15
|
5
|
7
|
15
|
|
Tremor
|
13
|
4
|
3
|
|
|
Vertigo
|
9
|
4
|
5
|
19
|
|
Cholinegic
antagonism
|
Cognitive
dysfunction
|
+++
|
0*
|
0*
|
0*
|
|
Alpha1
antagonism
|
Tiredness
|
9
|
variable
|
2
|
14
|
|
Somnolence
|
11
|
variable
|
2
|
23
|
|
Histaminergic
H1 antagonism
|
Sedation
|
+++
|
+
|
0
|
+
|
|
Weight
gain
|
++
|
variable
|
0
|
0
|
|
Effects
on driving
|
+++
|
0
|
0
|
0
|
|
5-HT
1 stimulation
|
Anxiety
|
+
|
++
|
+
|
++
|
|
5-HT2
stimulation
|
Sexual
dysfunction
|
+
|
+++
|
0
|
++
|
|
5-HT3
stimulation
|
Nausea
|
9
|
20
|
11
|
37
|
|
Alpha1
stimulation
|
Dysuria
|
+
|
0
|
+
|
0
|
|
Sweating
|
12
|
2
|
4
|
12
|
*
improvement
|
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1.
Puech A, Montgomery SA, Prost JF, Solles A, Briley M.
Milnacipran, a new serotonin and noradrenaline reuptake
inhibitor: an overview of its antidepressant activity and
clinical tolerability. Int Clin Psychopharmacol 1997; 12:
99-108.
2. Feighner JP. The role of venlafaxine
in rational antidepressant therapy. J Clin Psychiatry
1994; 55 Suppl A: 62-68.
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